Nicotine dependence is known to induce long-term neural adaptations in brain. The purpose of this study was to verify whether specific protein patterns related to nicotine self-administration states could also be detected in a peripheral tissue. A serum proteomic analysis was performed by 2-DE on samples taken at six time points: N, naïve; P, priming; S, self-administration; W, withdrawal; E, extinction; R, relapse. After image analysis, spot volume values were submitted to a principal component analysis and relevant comparisons were selected. In N versus S; S versus W; E versus R; S versus R and S versus E comparisons a clear separation between groups could be observed, suggesting that each self-administration state correlates with a speci...
All in-text references underlined in blue are linked to publications on ResearchGate, letting you ac...
<p>These Western blots illustrate that both nAChRs showed a significant (P<0.001) increase in protei...
Region-specific decreases of neurofilament proteins (NF) were described in the ventral tegmental are...
Nicotine dependence is known to induce long-term neural adaptations in brain. The purpose of this st...
Nicotine dependence is known to induce long-term neural adaptations in brain. The purpose of this st...
This study showed that specific protein patterns related to the nicotine dependence states exist in ...
In order to gain information about the effect triggered at the molecular level by nicotine, its neur...
In order to gain information about the effect triggered at the molecular level by nicotine, its neur...
<p>The expressions of proteins Porin, Mfs, SpmC, SpmA, Sapd, Pnao, NicA2, HspA, HspB, and NicA1 were...
Smoking is a risk factor in pancreatic disease; however, the biochemical mechanisms correlating smok...
BACKGROUND AND OBJECTIVE: Nicotine is one of the most common addictive substances that has many effe...
Nicotine-withdrawal symptoms have been indicated as a possible risk factor for neuropsychiatric even...
Nicotinic acetylcholine receptors (nAChRs) are pentameric cation channels that are expressed in the ...
Pain patients who are nicotine dependent report a significantly increased incidence and severity of ...
The identification of biomarkers that are altered following nicotine/tobacco exposure can facilitate...
All in-text references underlined in blue are linked to publications on ResearchGate, letting you ac...
<p>These Western blots illustrate that both nAChRs showed a significant (P<0.001) increase in protei...
Region-specific decreases of neurofilament proteins (NF) were described in the ventral tegmental are...
Nicotine dependence is known to induce long-term neural adaptations in brain. The purpose of this st...
Nicotine dependence is known to induce long-term neural adaptations in brain. The purpose of this st...
This study showed that specific protein patterns related to the nicotine dependence states exist in ...
In order to gain information about the effect triggered at the molecular level by nicotine, its neur...
In order to gain information about the effect triggered at the molecular level by nicotine, its neur...
<p>The expressions of proteins Porin, Mfs, SpmC, SpmA, Sapd, Pnao, NicA2, HspA, HspB, and NicA1 were...
Smoking is a risk factor in pancreatic disease; however, the biochemical mechanisms correlating smok...
BACKGROUND AND OBJECTIVE: Nicotine is one of the most common addictive substances that has many effe...
Nicotine-withdrawal symptoms have been indicated as a possible risk factor for neuropsychiatric even...
Nicotinic acetylcholine receptors (nAChRs) are pentameric cation channels that are expressed in the ...
Pain patients who are nicotine dependent report a significantly increased incidence and severity of ...
The identification of biomarkers that are altered following nicotine/tobacco exposure can facilitate...
All in-text references underlined in blue are linked to publications on ResearchGate, letting you ac...
<p>These Western blots illustrate that both nAChRs showed a significant (P<0.001) increase in protei...
Region-specific decreases of neurofilament proteins (NF) were described in the ventral tegmental are...